Dometic is a Dopamine antagonist .Because it does not readily enter the central nervous system, its effects are confined to the periphery and acts principally at the receptor in the chemoreceptor trigger zone.
1. Stimulation of gut mobility
a) Non-ulcer dyspepsia
b) Esophageal reflux, reflux esophagitis and gastritis
c) Diabetic gastroparesis
d) Functional dyspepsia
e) Speeding barium transit in 'follow-through' radiological studies
2. Prevention and symptomatic relief of acute nausea and vomiting from any cause
including cytotoxic therapy, radio therapy and anti-parkinsonism therapy
3. In the treatment of migraine.
The recommended oral dose for
Adults : 10 - 20 mg every 4 - 8 hours daily
Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Note : Domperidone tablet and suspension should be taken 15 - 30 minutes before a meal.
For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier.
Domperidone may produce hyperprolactinemia(1.3% frequency). This may result in galactorrhea, breast enlargement and soreness and reduced libido. Dry mouth (1.9%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with Domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.
Pregnant women : The safety of Domperidone has not been proven and it is therefore not recommended during pregnancy.Animal studies have not demonstrated teratogenic effects on the fetus.
Lactating mother : Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.