Maxzon (Ceftriaxone) is a sterile, semi-synthetic, third generation broad-spectrum cephalosporin antibiotic for intravenous/intramuscular administration. The bactericidal activity of ceftriaxone results from inhibition of cell wall synthesis, Ceftriaxone has a high degree of stability in the presence of beta-lactamases both penicillinases and cephalosporinases of gram-positive and gram-negative bacteria.
Ceftriaxone is most effective against the following microorganisms: Gram-positive bacteria; Staphylococcus aureus (including penicillinase producing strains). S. epidermis, S. pneumoniae & S. bovis. Gram-negative bacteria: Escherichia coli, Heamophilus influenzae (including penicillinase- producing strains), Neisseria gonorrhoeae, Neisseria meningitidis, Proteus mirabilis & Proteus vulgaris. A remarkable feature of ceftriaxone is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine; the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. The drug is highly protein bound (95%).