• Careers

    Onepro

    Esomeprazole

    Description

    Esomeprazole (Onepro) is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H /K ATPase in the gastric parietal cell. By acting specifically on the proton pump, Onepro blocks the final step in acid production, thus reducing gastric acidity.

     

    Indications and Usage

    • Treatment of Gastroesophageal Reflux Disease (GERD)

    -Healing of Erosive Esophagitis

    -Maintenance of Healing of Erosive Esophagitis

    -Symptomatic Gastroesophageal Reflux Disease

    • pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
    • Zollinger-Ellison Syndrome
    • Acid Related Dyspepsia
    • Duodenal and Gastric Ulcer
    Onepro 20 tablet: Each delayed release tablet contains Esomeprazole Magnesium Trihydrate BP equivalent to Esomeprazole 20 mg. Onepro 40 tablet: Each delayed release tablet contains Esomeprazole Magnesium Trihydrate BP equivalent to Esomeprazole 40 mg. Onepro 20 capsule: Each capsule contains Esomeprazole Magnesium Trihydrate BP equivalent to Esomeprazole 20 mg as Enteric coated pellets. Onepro 40 capsule: Each capsule contains Esomeprazole Magnesium Trihydrate BP equivalent to Esomeprazole 40 mg as Enteric coated pellets.
    • Treatment of Gastroesophageal Reflux Disease (GERD) -Healing of Erosive Esophagitis -Maintenance of Healing of Erosive Esophagitis -Symptomatic Gastroesophageal Reflux Disease • H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence • Zollinger-Ellison Syndrome • Acid Related Dyspepsia • Duodenal and Gastric Ulcer
    Onepro delayed release tablet/capsule should be swallowed whole and taken at least one hour before eating. The majority of patients are healed within 4 to 8 weeks. For patients who do not heal after 4-8 weeks, an additional 4-8 weeks of treatment may be considered. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered.
    Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.
    Symptomatic response to therapy with Esomeprazole does not preclude the presence of gastric malignancy. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole, of which Esomeprazole is an enantiomer.
    In general, Esomeprazole was well tolerated in both short- and long-term clinical trials. The most frequently occurring adverse events (≥1%) are headache and diarrhea. Nausea, flatulence, abdominal pain, constipation and dry mouth occurred at similar rates among patients taking Esomeprazole.
    Drug interaction studies have shown that Esomeprazole does not have any clinically significant interactions with Phenytoin, Warfarin, Quinidine, Clarithromycin or Amoxicillin. Esomeprazole inhibits gastric acid secretion. Therefore, Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, Ketoconazole, Iron salts and Digoxin). Coadministration of oral contraceptives, Diazepam, Phenytoin or Quinidine did not seem to change the pharmacokinetic profile of Esomeprazole.
    In Pregnancy: Pregnancy Category B. This drug should be used during pregnancy only if clearly needed. In Lactation: The excretion of Esomeprazole in milk has not been studied. As Esomeprazole is likely to be excreted in human milk, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
    Onepro 20 tablet: Each box contains 6 Alu-Alu blister strips of 10 tablets. Onepro 40 tablet: Each box contains 3 Alu-Alu blister strips of 10 tablets. Onepro 20 capsule: Each box contains 3 Alu-Alu blister strips of 10 capsules. Onepro 40 capsule: Each box contains 3 Alu-Alu blister strips of 10 capsules.

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