Murein 500 mg Cap

Flucloxacillin

Description

Composition
Murein 500 Capsule: Each capsule contains Flucloxacillin Sodium BP equivalent
to Flucloxacillin 500 mg.
Pharmacology
Flucloxacillin is an isoxazolyl penicillin of the ß-lactam group of antibiotics which
exerts a bactericidal effect upon many Gram-positive organisms including
ß-lactamase-producing staphylococci and streptococci. It is not active against
methicillin-resistant staphylococci.
Indication
Flucloxacillin is indicated for the treatment of infections due to Gram – positive
organisms. Skin and soft tissue infections: boils, abscesses, carbuncles,
furunculosis, cellulitis; infected skin conditions, e.g. ulcer, eczema and acne;
infected wounds, infected burns, protection for skin grafts, impetigo. Respiratory
tract infections: pneumonia, lung abscess, empyema, sinusitis, pharyngitis,
tonsillitis, quinsy, otitis media and externa. Other infection caused by Flucloxacillin –
sensitive organisms: osteomyelitis, enteritis, endocarditis, urinary tract infection,
meningitis, septicemia. Flucloxacillin is also indicated for use as a prophylactic
agent during major surgical procedures where appropriate; for example,
cardiothoracic and orthopedic surgery.
Dose & Administration
a) Route of administration: Oral
Oral doses should be administered half to one hour before meals.
Usual adult dosage (including elderly patients): 250 mg four times daily.
In severe infections: dosage should be doubled.
In osteomyelitis and endocarditis: up to 8 gm daily, in divided doses 6 to 8 hourly.
In case of secondary bacterial infection in chicken pox: Flucloxacillin 500 mg 6
hourlies should be prescribed.
Usual children dosage: 2-10 years: half of the adult dose.
Under 2 years: quarter of the adult dose.
Contra-indication
Flucloxacillin should not be given to penicillin or cephalosporine hypersensitive
patients.
Warning and Precaution
History of allergy, renal impairment, false-positive urinary glucose.
Side effects
a) Common: Side effects as with other penicillins, are uncommon and mainly of a
mild and transitory nature.
b) Rare: Gastro-intestinal upsets (e.g., nausea, diarrhea) and skin rashes have
been reported. If a skin rash occurs, treatment should be discontinued.
Use in Pregnancy & Lactation
The use of Flucloxacillin in pregnancy should be reserved for cases considered
essential by the clinician. Use of the drug in the second and third trimesters may
result in the sensitization of the fetus. During lactation, trace quantities of
penicillin’s can be detected in breast milk.
Use in Children & Adolescents
Please see the dose and administration.
Drug interaction
a) With medicine: The administration of probenecid with Flucloxacillin results in
higher serum peak concentrations and prolongs the time that therapeutic
concentrations of Flucloxacillin are achieved in serum. Physical incompatibility
and/or loss of activity of Flucloxacillin in solution have been reported when given
with gentamicin sulphate, streptomycin sulphate and vitamin mixtures.
b) With food & other: Flucloxacillin is best taken on an empty stomach, one hour
before eating food. This is because your body may absorb less flucloxacillin after a
meal, making it less effective.
Overdose
You may need urgent medical attention. Symptoms of an overdose may include
nausea, vomiting and diarrhea.
Important: Flucloxacillin can cause severe liver damage, which can make the skin
and whites portion of the eyes turn yellow in color.
Storage
Store below 30°C. Protect from light. Keep all medicines out of reach of children.
Packing
Murein 500 Capsule: Each box contains 28 (7×4’s) capsules in blister pack.

Murein 500: Each capsule contains Flucloxacillin Sodium BP equivalent to Flucloxacillin 500 mg.
• Skin and Soft Tissue Infections: Boils, abscesses, carbuncles, furunculosis, infected wounds, infected burns, protection of skin grafts, otitis media and externa, impetigo. • Infected Skin Conditions: Ulcer, eczema and acne. • Respiratory Tract Infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy. • Other infections caused by Flucloxacillin-sensitive organisms such osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia. Flucloxacillin is also indicated for use as a prophylactic agent during major surgical procedures where appropriate, for example, cardiothoracic and orthopaedic surgery.
Adults (including elderly patients): Oral: 500 mg three to four times a day. Oral doses should be administered 1 hour before meal.   Children 2-10 years: Half of adult dose. Under 2 years: One fourth of adult dose. Children have been given doses of 12.5mg/kg body weight four times a day.   Patients with impaired renal function: As common with other penicillins, Flucloxacillin usage in patients with renal impairment does not usually require dosage reduction. However, in the presence of severe renal failure (creatinine clearance<10 ml/min) a reduction in dose or an extension of dosage interval should be considered.
Flucloxacillin should not be given to penicillin-hypersensitive patients.
Hypersensitive to penicillin or cephalosporin. Older patients receiving Flucloxacillin for longer than two weeks are at a risk of jaundice. In the presence of severe renal failure (creatinine clearance < 10ml/min) a reduction in dosage or an extension of dose interval should be considered
There have been some common side effects of GIT such as nausea, vomiting, diarrhoea, dyspepsia and other minor gastrointestinal disturbances. Besides these rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis and cholestatic jaundice have been reported.
The administration of Probenecid with Flucloxacillin results in higher peak serum concentrations of Flucloxacillin. Physical incompatibility and/or loss of activity of Flucloxacillin have been reported when given with Gentamycin Sulphate, Streptomycin Sulphate and Vitamin mixtures
Use in pregnancy Penicillins are generally considered safe for use in pregnancy. Animal studies with Flucloxacillin have shown no teratogenic effect. Use in lactation Flucloxacillin is excreted in breast milk in trace amounts. Flucloxacillin may be administered during the period of lactation.
Although overdosage problems are unlikely to occur with penicillins, and should be treated symptomatically.
Murein 500: Each box contains 7 strips of 4 capsules.