Flucloxacillin is a narrow-spectrum antibiotic with considerable activity against the following common Gram-positive organisms:

  • Penicillinase producing Staphylococcus aureus
  • Penicillinase sensitive Staphylococcus aureus
  • ß-haemolytic streptococci (Streptococcus pyogenes)
  • Streptococcus pneumoniae

It has little activity against Gram-negative bacilli. However, the Gram-negative organisms Neisseria gonorrhoeae and Neisseria meningitidis come within the range of activity. Flucloxacillin kills bacteria by inhibiting the formation of cell wall of bacteria.

Murein 500: Each capsule contains Flucloxacillin Sodium BP equivalent to Flucloxacillin 500 mg.
• Skin and Soft Tissue Infections: Boils, abscesses, carbuncles, furunculosis, infected wounds, infected burns, protection of skin grafts, otitis media and externa, impetigo. • Infected Skin Conditions: Ulcer, eczema and acne. • Respiratory Tract Infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy. • Other infections caused by Flucloxacillin-sensitive organisms such osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia. Flucloxacillin is also indicated for use as a prophylactic agent during major surgical procedures where appropriate, for example, cardiothoracic and orthopaedic surgery.
Adults (including elderly patients): Oral: 500 mg three to four times a day. Oral doses should be administered 1 hour before meal.   Children 2-10 years: Half of adult dose. Under 2 years: One fourth of adult dose. Children have been given doses of 12.5mg/kg body weight four times a day.   Patients with impaired renal function: As common with other penicillins, Flucloxacillin usage in patients with renal impairment does not usually require dosage reduction. However, in the presence of severe renal failure (creatinine clearance<10 ml/min) a reduction in dose or an extension of dosage interval should be considered.
Flucloxacillin should not be given to penicillin-hypersensitive patients.
Hypersensitive to penicillin or cephalosporin. Older patients receiving Flucloxacillin for longer than two weeks are at a risk of jaundice. In the presence of severe renal failure (creatinine clearance < 10ml/min) a reduction in dosage or an extension of dose interval should be considered
There have been some common side effects of GIT such as nausea, vomiting, diarrhoea, dyspepsia and other minor gastrointestinal disturbances. Besides these rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis and cholestatic jaundice have been reported.
The administration of Probenecid with Flucloxacillin results in higher peak serum concentrations of Flucloxacillin. Physical incompatibility and/or loss of activity of Flucloxacillin have been reported when given with Gentamycin Sulphate, Streptomycin Sulphate and Vitamin mixtures
Use in pregnancy Penicillins are generally considered safe for use in pregnancy. Animal studies with Flucloxacillin have shown no teratogenic effect. Use in lactation Flucloxacillin is excreted in breast milk in trace amounts. Flucloxacillin may be administered during the period of lactation.
Although overdosage problems are unlikely to occur with penicillins, and should be treated symptomatically.
Murein 500: Each box contains 7 strips of 4 capsules.