Composition
NX Plus 375/20 Tablet: Each tablet contains delayed release Naproxen Sodium USP equivalent to Naproxen 375 mg and immediate
release Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
NX Plus 500/20 Tablet: Each tablet contains delayed release Naproxen Sodium USP equivalent to Naproxen 500 mg and immediate
release Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
Pharmacology
NX Plus consists of an immediate release Esomeprazole magnesium layer and an enteric coated Naproxen core. As a result
Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine.
Naproxen is a NSAID with analgesic and antipyretic properties. The mechanism of action of Naproxen is to inhibition of the prostaglandin
synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in
the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing
gastric acidity.
Indication
It is indicated for the relief of signs and symptoms of osteoarthritis, rehumatoid arthritis and ankylosing spondylitis, dysmenorrhoea and
to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID associated gastric ulcers.
Dose and Administration
a) Route of administration: Oral
Carefully consider the potential benefits and risks of NX Plus and other treatment options before deciding to use NX Plus. Use the lowest
effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total
daily dose of 40mg is more appropriate, a different treatment should be considered.
Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis and dysmenorrhoea | NX Plus 375/20 | 1 Tablet twice daily |
NX Plus 500/20 |