Doxofylline is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxofylline selectively inhibits phosphodiesterase-4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxofylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxofylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production.

Windo 200 Tablet: Each film coated tablet contains Doxofylline INN 200 mg . Windo 400 Tablet: Each film coated tablet contains Doxofylline INN 400 mg .
Doxofylline is used to treat asthma, COPD and bronchospasm.
Adults: 400 mg tablet daily in the evening. However, in certain cases, 400 mg tablet twice daily is recommended on the basis of the clinical response. Doses as high as 1200 mg/day (400 mg tablet 3 times daily) may also be prescribed. Elderly: In elderly patients with concomitant cardiovascular, hepatic and renal diseases recommended dosage should be 200 mg tablet twice daily. Children (above 6 years of age): The recommended dosage of Doxofylline is 6 mg/kg twice daily. The dose may be increased up to 18 mg/kg daily on the basis of clinical response.
This is contraindicated for individuals who have shown hypersensitivity to Doxofylline and its components. It is also contraindicated in patients with acute myocardial infarction, hypotension, and in lactating women
The half-life of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol and anti-flu vaccine. In these cases, a lower dose of Doxofylline may be needed. Phenytoin, other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half-life. In these cases higher doses of Doxofylline may be needed.
Doxofylline rarely causes serious side effects. However, possible side effects are similar for taking excess amount of caffeine. These include: nausea, vomiting, headache, upset stomach and heartburn.
Doxofylline should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthines. Like other xanthines, concomitant therapy with erythromycin. troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol and anti-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels. No evidence of a relationship between Doxofylline serum concentrations and toxic events have been reported.
Animal reproduction studies indicate that, Doxophylline does not cause fetal harm when administered to pregnant animals or cannot affect reproduction capacity. However, since there is limited experience in human during pregnancy, xanthines should be given to pregnant women only if clearly needed. Doxophylline is contraindicated in nursing mothers.
Although no major arrhythmias have been documented with Doxofylline, the occurrence of major cardiac rhythm disturbances cannot be excluded in case of overdosage of xanthine compounds. If a potential oral overdose is established, the patient may present with seizures; this symptom could be the first sign of intoxication. Adverse reactions may cause withdrawal from treatment.
Windo 200 Tablet: Each box contains 5 blister strips of 10 tablets. Windo 400 Tablet: Each box contains 3 blister strips of 10 tablets.